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M9490037.TXT
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1994-09-03
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Document 0037
DOCN M9490037
TI Major expansion of CD8+ T cells with a predominant V beta usage during
the primary immune response to HIV [see comments]
DT 9411
AU Pantaleo G; Demarest JF; Soudeyns H; Graziosi C; Denis F; Adelsberger
JW; Borrow P; Saag MS; Shaw GM; Sekaly RP; et al; Laboratory of
Immunoregulation, National Institute of Allergy and; Infectious
Diseases, National Institutes of Health, Bethesda,; Maryland 20892.
SO Nature. 1994 Aug 11;370(6489):463-7. Unique Identifier : AIDSLINE
MED/94322938
CM Comment in: Nature 1994 Aug 11;370(6489):416
AB A SIGNIFICANT proportion (up to 70%) of individuals experience an acute
clinical syndrome of varying severity associated with primary infection
with the human immunodeficiency virus (HIV). We report here studies on
six individuals who showed an acute HIV syndrome which generally
resolved within four weeks, concomitant with a dramatic downregulation
of viraemia. To characterize the T-cell-mediated primary immune response
to HIV, we used combined semiquantitative polymerase chain reaction
assay and cytofluorometry to analyse the T-cell antigen receptor
repertoire in sequential peripheral blood mononuclear cells from the
patients. We found major oligoclonal expansions in a restricted set of
variable-domain beta-chain (V beta) families. Cells expressing the
expanded V beta s predominantly expressed the CD8 T-cell differentiation
antigen and mediated HIV-specific cytotoxicity. Major oligoclonal
expansions of these CD8+ T lymphocytes may represent an important
component of the primary immune response to viral infections and may
help to clarify both the immunopathogenic and the protective mechanisms
of HIV infection.
DE Adolescence Adult Amino Acid Sequence *Antigens, CD8 Cell Line,
Transformed Cells, Cultured Clone Cells Cytotoxicity, Immunologic
DNA Female Flow Cytometry Human HIV/*IMMUNOLOGY HIV
Infections/*IMMUNOLOGY Immunogenetics Immunophenotyping Male
Molecular Sequence Data Polymerase Chain Reaction Prospective Studies
Receptors, Antigen, T-Cell, alpha-beta/*GENETICS Support, Non-U.S.
Gov't Support, U.S. Gov't, P.H.S. T-Lymphocyte Subsets/*IMMUNOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).